AI-Assisted Causal Inference and Mediation Analyses of Environmental and Psychosocial Determinants of Subjective Cognitive Difficulties in the All of Us Research Program

תקציר מקורי באנגליתarXiv:2607.22640v1 Announce Type: cross Abstract: Short-term environmental exposures have been linked to cognitive and behavioral outcomes, although many reported associations may reflect broader geographic and contextual differences. Using longitudinal data from the All of Us Research Program (2018--2024), we linked daily weather and air-pollution exposures to repeated attention-related and subjective cognitive outcomes. Associations were evaluated using pooled, fixed-effects, lagged, and event-study analyses. Additional machine-learning analyses were conducted to explore potential heterogeneity and latent psychosocial structure. Replication analyses were performed using the 2024 Behavioral Risk Factor Surveillance System (BRFSS). Several environmental exposure measures showed small assoc