Generative Artificial Intelligence in Bioinformatics: A Systematic Review of Models, Applications, and Methodological Advances

תקציר מקורי באנגליתarXiv:2511.03354v2 Announce Type: replace-cross Abstract: Generative artificial intelligence (GenAI) is transforming bioinformatics by advancing genomics, proteomics, transcriptomics, structural biology, and drug discovery. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework, this review addresses six research questions to evaluate influential GenAI strategies in terms of methodological innovation, predictive performance, specialization, limitations, and data use. RQ1 shows that GenAI supports sequence analysis, molecular design, and integrative data modelling, often outperforming traditional methods through improved pattern recognition and generation. RQ2 finds that specialized architectures generally outperform general-purpose models because of doma