Making Single-Cell Data Distillation Auditable: Traceable Real-Cell Coresets via Discrete Min-Max Selection

תקציר מקורי באנגליתarXiv:2607.19426v1 Announce Type: cross Abstract: Single-cell datasets are increasingly costly to store, audit, and reuse for model training. Dimensionality reduction and dataset distillation can reduce this burden, but conventional distillation methods often produce synthetic expression profiles that cannot be traced to an assayed cell. We formulate traceable single-cell data distillation as retaining original cell identifiers and gene symbols under fixed cell and gene budgets. The resulting training subset remains connected to measured counts, labels, and assay metadata, so unexpected predictions can be checked against their source data. We propose two real-cell selectors. Fixed-CF uses static characteristic-function matching. Minmax-CF solves an entropy-regularized discrete min--max pro