תיקון מודלים מטבוליים בקנה מידה גנומי

תקציר מקורי באנגליתarXiv:2610.11627v1 Announce Type: new Abstract: Repairing scientific models from functional observations differs fundamentally from supervised prediction: feedback may certify a solution without revealing which structural correction is responsible. We study this setting for genome-scale metabolic model (GEM) repair, where multiple reaction edits can explain the same phenotypes and many apparently distinct edits correspond to the same biological mechanism. This many-to-one structure creates a hidden failure mode for conventional exploration: diversity in the output space need not translate into diversity of scientific hypotheses. We introduce QuotientPO, which collapses equivalent repairs into canonical mechanisms and optimizes exploration directly over the resulting quotient space. To make