עיצוב ובקרה אופטימליים של דיגיטל תאומים ביולוגיים

תקציר מקורי באנגליתarXiv:2610.09505v1 Announce Type: cross Abstract: We develop a bias-aware digital-twin calibration and control framework for multiscale bioprocess models within a biological systems-of-systems (Bio-SoS) paradigm. The digital twin is represented by a stochastic differential equation (SDE) model and calibrated from sparse, discrete observations using quasi-likelihood estimation and adjoint sensitivity analysis. SDE generator-based moment expansions characterize truncation-induced parameter bias, while forward-backward adjoints quantify how calibration uncertainty propagates to value functions and policy performance. The resulting parameter-error distribution supports both policy-directed adaptive experimental design and uncertainty-aware policy optimization through a second-order Gaussian-av