MARCO: The Radioactive Watermark for Protein Generative Models

תקציר מקורי באנגליתarXiv:2610.08316v1 Announce Type: cross Abstract: Protein Generative Models (PGMs) have revolutionized structural biology by enabling the design of complex 3D protein structures from sequence data. However, this breakthrough introduces a dual-use challenge, exposing high-value PGMs to economic risks like unauthorized model extraction and biosecurity threats such as biohazard synthesis. To mitigate these threats, we propose \textbf{MARCO} (\textsc{COnformation waterMARk}), the first radioactive watermarking framework specifically tailored for PGMs. MARCO establishes a Dual-Layer defense that simultaneously protects intellectual property and ensures the forensic traceability of potential biosecurity misuses. (i) To preserve efficiency, MARCO iteratively embeds watermarks during diffusion rev