Fold'EM: Direct atomic structure inference from Cryo-EM particles

תקציר מקורי באנגליתarXiv:2610.01358v2 Announce Type: replace-cross Abstract: Single-particle cryo-electron microscopy (cryo-EM) has become a widely adopted technique for biomolecular structure determination. The conventional cryo-EM computational pipeline first combines many particle images to reconstruct an electrostatic potential (ESP) map and then fits an atomic model to the recovered map. Density reconstruction has high sample complexity, requiring large numbers of particle images and making structure determination high-cost and low-throughput, particularly for heterogeneous samples. Downstream atomic model building, in turn, becomes increasingly difficult as the resolution of the reconstructed map deteriorates. Protein structure prediction models provide strong sequence-derived priors on atomic structur