Accelerator Choice Is Not Enough: AlphaFold2 Inference on Cloud TPUs

תקציר מקורי באנגליתarXiv:2609.34818v2 Announce Type: replace-cross Abstract: AlphaFold2 is written in JAX, so the same inference code compiles and runs unchanged on CPUs, GPUs and Google Cloud TPUs. That portability makes the accelerator look like the main decision a user has to make. We show that it is not. Running one AlphaFold2 inference workload across a Colab CPU runtime, an NVIDIA T4 GPU and a dedicated eight-chip Cloud TPU v5e slice, we find a large hardware advantage for the TPU, 0.47 s per call in steady state on a single chip against 13.1 s on the T4 in the same measurement campaign, and three ways in which the software layer decides how much of it a user actually gets. The default execution path uses one chip of the eight, and at list prices the idle capacity makes the slice cost about as much per