Language as the Interface: Foundation-Model Contrastive Learning Links Transcriptomes and Electrophysiology

תקציר מקורי באנגליתarXiv:2609.37024v1 Announce Type: new Abstract: Integrating transcriptomic and electrophysiological data is essential for building multimodal foundation models for neuroscience. Patch-seq provides paired measurements of gene expression and intrinsic electrophysiology from the same neuron, establishing a basis for training cross-modal models. Here we introduce LangPatch, a foundation-model-based contrastive learning framework that uses paired Patch-seq data to align pretrained GenePT representations with electrophysiological phenotypes through a language-based interface. Gene descriptions and verbalized electrophysiological profiles are embedded by the same frozen text encoder. A context adapter and projection modules connect the modalities through paired contrastive learning. Across mouse